The TargetBASE® system is a browser and information management tool for exploring family relationships between proteins that either are drug targets or are related to known drug targets.
![[TargetBASE image collation]](images/TargetBASE-overview.png)
Central to the TargetBASE® experience is the flexible tree visualiser (reTreevTM), originally written in Java by David Parry-Smith. It enables you to see the relationships between target proteins at a glance. With clickable leaves and the ability to drill down to higher resolution trees, scrolling long lists in the web browser is a thing of the past.
Tree layout is a well known and non-trivial problem in phylogenetics. The reTreevTM algorithm is fast, accurate and flexible. It requires no added user input to determine the positioning of labels.
TargetBASE® contains curated information on the following families of protein targets
- Phosphodiesterases (PDEs)
- G-Protein-coupled receptors (GPCRs)
- Potassium channels (ion channels)
- Kinases
- Phosphatases
- Histones
TargetBASE is available under commercial licence only from ChiBio Informatics Limited, which includes ongoing support. Access is free to academics - contact ChiBio for details. It is available in the following formats:
- a preconfigured BioChineTM to run on a Windows XP or Vista system
- a client server install under Solaris 10 Unix or Linux
- a web application accessed from your local browser over the Internet
For a demonstration of data from the PDE and phosphatase families please contact ChiBio.
See the BioChinesTM page for further information on system requirements for a ChiBio Informatics BioChineTM.
Page last updated: Mon 1 Mar 2010 14:25:36 GMT
ChiBio Informatics is a business name (trading name) of ChiBio Informatics Limited
ChiBio Informatics Limited is a company registered in England and Wales No. 5817568
Registered Office: 11 Murray Street London NW1 9RE
